Please fill out the required fields.
Calculates CrCl according to the Cockcroft-Gault equation.
Creatine clearance calculator
After calculating a creatinine clearance, providers should consider calculating an actual GFR as well, to determine the staging/severity of a patient’s chronic kidney disease.
|CKD stage||GFR level (mL/min/1.73 m2)|
|Stage 1||≥ 90|
|Stage 2||60 – 89|
|Stage 3||30 – 59|
|Stage 4||15 – 29|
|Stage 5||< 15|
Cockcroft-Gault CrCl, mL/min = (140 – age) × (weight, kg) × (0.85 if female) / (72 × Cr)
Ideal body weight (IBW), Devine equation:
- IBW, kg (male) = 50 + [ 2.3 × (height, inches – 60) ]
- IBW, kg (female) = 45.5 + [ 2.3 × (height, inches – 60) ]
Adjusted body weight (ABW), kg = IBW, kg + 0.4 × (actual body weight, kg – IBW, kg)
Facts and figures
The most common formula for determining creatinine clearance, which estimates glomerular filtration rate (GFR); creatinine clearance may over-estimate GFR by 10-20%, but still remains the standard for drug dosing adjustments.
Based on several papers and expert opinions, we provide adjustments to the Cockcroft-Gault equation based on body weight and BMI, as it appears to become less accurate in weight extremes (underweight and particularly overweight/obesity). As recommended by Brown et al and Winter et al, adjustments and estimates are made as follows:
|Underweight BMI <18.5||Calculation uses actual/total body weight (i.e., no adjustment)|
|Normal weight BMI 18.5-24.9||Calculation uses ideal body weight, range uses actual body weight|
|Overweight / obese BMI ≥25||Calculation uses adjusted body weight, range uses ideal body weight|