Please fill out the required fields.
Creatinine Clearance
(Cockcroft-Gault Equation)
Calculates CrCl according to the Cockcroft-Gault equation.
Creatine clearance calculator
Result
Advice
After calculating a creatinine clearance, providers should consider calculating an actual GFR as well, to determine the staging/severity of a patient’s chronic kidney disease.
CKD stage | GFR level (mL/min/1.73 m2) |
---|---|
Stage 1 | ≥ 90 |
Stage 2 | 60 – 89 |
Stage 3 | 30 – 59 |
Stage 4 | 15 – 29 |
Stage 5 | < 15 |
Formula
Cockcroft-Gault CrCl, mL/min = (140 – age) × (weight, kg) × (0.85 if female) / (72 × Cr)
Ideal body weight (IBW), Devine equation:
- IBW, kg (male) = 50 + [ 2.3 × (height, inches – 60) ]
- IBW, kg (female) = 45.5 + [ 2.3 × (height, inches – 60) ]
Adjusted body weight (ABW), kg = IBW, kg + 0.4 × (actual body weight, kg – IBW, kg)
Facts and figures
The most common formula for determining creatinine clearance, which estimates glomerular filtration rate (GFR); creatinine clearance may over-estimate GFR by 10-20%, but still remains the standard for drug dosing adjustments.
Based on several papers and expert opinions, we provide adjustments to the Cockcroft-Gault equation based on body weight and BMI, as it appears to become less accurate in weight extremes (underweight and particularly overweight/obesity). As recommended by Brown et al and Winter et al, adjustments and estimates are made as follows:
Underweight BMI <18.5 | Calculation uses actual/total body weight (i.e., no adjustment) |
Normal weight BMI 18.5-24.9 | Calculation uses ideal body weight, range uses actual body weight |
Overweight / obese BMI ≥25 | Calculation uses adjusted body weight, range uses ideal body weight |
Literature
Original/primary reference
Other references
Winter MA, Guhr KN, Berg GM. Impact of various body weights and serum creatinine concentrations on the bias and accuracy of the Cockcroft-Gault equation. Pharmacotherapy. 2012 Jul;32(7):604-12. doi:10.1002/j.1875-9114.2012.01098.x. Epub 2012 May 10. PubMed PMID: 22576791.
Brown DL, Masselink AJ, Lalla CD. Functional range of creatinine clearance for renal drug dosing: a practical solution to the controversy of which weight to use in the Cockcroft-Gault equation. Ann Pharmacother. 2013 Jul-Aug;47(7-8):1039-44. doi: 10.1345/aph.1S176. Epub 2013 Jun 11. Review. PubMed PMID: 23757387.